Full Name: Shigella pathogenicity island 3
Location: 1~20962 bp
Size: 21 Kbp
Contain a functional aerobactin operon.
SHI-2 also contains an aerobactin operon, but SHI-3 is distinct from SHI-2. Acquisition of SHI-3 is associated with a deletion of more than 6 kb relative to the E. coli K-12 sequence, including cadA, lysine decarboxylase. Cadaverine, produced by the decarboxylation of lysine, inhibits Shigella enterotoxic activity. So acquisition of SHI-3 is associated with enhancing the virulence of Shigella.
Purdy GE, Payne SM, 2001. The SHI-3 iron transport island of Shigella boydii 0-1392 carries the genes for aerobactin synthesis and transport. J. Bacteriol. 183(14):4176-4182.
||Back to Top