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Pathogenicity islands in EHEC : LEE(EHEC)


LEE(EHEC) (EHEC)


View the legend tRNA-Sec intL Z5088 Z5089 Z5091 Z5092 Z5093 Z5094 Z5095 Z5096 Z5097 Z5098 espF escG escF cesD2 espB espD espA sepL escD eae cesT tir tir map cesF espH sepQ/escQ escP escO escN escV cesL sepZ/espZ escI escJ sepD escC cesD glrA glrR etgA escU escT escS escR escL escK cesAB escE ler espG Z5143

Full Name: Locus of enterocyte effacement
Species: coli
Strain: O157:H7 EDL933
Replicon: chromosome
Accession: AE005174 (NC_002655)
Location: 4649752~4692545 bp
Size: 43 Kbp
G+C content (%): 40.91/50.8 (PAI/Genome)
Inserted locus:
selC tRNA
Phenotype:
Similar to the EPEC LEE, this PAI is involved in the production of proteins associated with intimate adherence to intestinal epithelial cells, initiation of host signal transduction pathways, and the formation of A/E lesions.
Remark:
The EHEC LEE comprises 43,359bp in comparison to 35,624bp for EPEC LEE, and contains 41 genes are common to both the EHEC and EPEC LEEs. The ORFs that are not present in the EPEC LEE fall within a putative prophage, designated 933L, that is located next to the selC locus. The 933L prophage is a member of the P4 family of cryptic prophages.
A few genes in EPEC and EHEC LEEs show markedly higher variablility: espB (25.99% difference), espD (19.64%), and espA (15.37%), eae (12.77%) and the intimin receptor gene, tir (33.52%).
Reference:
Elliott SJ, et al., 2000. The locus of enterocyte effacement (LEE)-encoded regulator controls expression of both LEE- and non-LEE-encoded virulence factors in enteropathogenic and enterohemorrhagic Escherichia coli. Infect. Immun. 68(11):6115-6126.
Iyoda S, et al., 2006. The GrlR-GrlA regulatory system coordinately controls the expression of flagellar and LEE-encoded type III protein secretion systems in enterohemorrhagic Escherichia coli. J Bacteriol 188(16):5682-92.
Naylor SW, et al., 2005. Escherichia coli O157 : H7 forms attaching and effacing lesions at the terminal rectum of cattle and colonization requires the LEE4 operon. Microbiology 151(Pt 8):2773-81.
Schmidt MA, 2010. LEEways: tales of EPEC, ATEC and EHEC. Cell Microbiol 12(11):1544-52.








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