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Pathogenicity islands in EPEC : EspC island


EspC island (EPEC)


View the legend rorf1 orf1 rorf2 rorf3 orf2 orf3 espC orf5 rorf4 rorf5 orf6.1 orf6.2 orf6.3 rorf6 orf7 orf8

Species: coli
Strain: E2348/69
Replicon: chromosome(EspC island)
Accession: AF297061
Location: 1~15195 bp
Size: 15 Kbp
G+C content (%): 40.5/50.8 (PAI/Genome)
Phenotype:
Contains two loci associated with virulence, espC and orf3, a gene encoding a protein with homology to VirA in S. flexneri.
Remark:
Present in some but not all lineages of EPEC. The role of this PAI is an accessory virulence factor in this subset of EPEC strains.
Reference:
Mellies JL, et al., 2001. espC pathogenicity island of enteropathogenic Escherichia coli encodes an enterotoxin. Infect. Immun. 69(1):315-324.
Schmidt H, Hensel M, 2004. Pathogenicity islands in bacterial pathogenesis. Clin. Microbiol. Rev. 17(1):14-56.
Stein M, et al., 1996. Characterization of EspC, a 110-kilodalton protein secreted by enteropathogenic Escherichia coli which is homologous to members of the immunoglobulin A protease-like family of secreted proteins. J. Bacteriol. 178(22):6546-6554.








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