EspC island (EPEC)
Replicon: chromosome(EspC island)
Location: 1~15195 bp
Size: 15 Kbp
G+C content (%): 40.5/50.8 (PAI/Genome)
Contains two loci associated with virulence, espC and orf3, a gene encoding a protein with homology to VirA in S. flexneri.
Present in some but not all lineages of EPEC. The role of this PAI is an accessory virulence factor in this subset of EPEC strains.
Mellies JL, et al., 2001. espC pathogenicity island of enteropathogenic Escherichia coli encodes an enterotoxin. Infect. Immun. 69(1):315-324.
Schmidt H, Hensel M, 2004. Pathogenicity islands in bacterial pathogenesis. Clin. Microbiol. Rev. 17(1):14-56.
Stein M, et al., 1996. Characterization of EspC, a 110-kilodalton protein secreted by enteropathogenic Escherichia coli which is homologous to members of the immunoglobulin A protease-like family of secreted proteins. J. Bacteriol. 178(22):6546-6554.