Full Name: Salmonella pathogenicity island 2
Species: enterica (serovar typhimurium)
Location: 1459926~1501800 bp
Size: 41 Kbp
Encodes a second TTSS that is essential for intracellular growth.
Necessary in the systemic phase of inection.
Present in all subspecies of S. enterica but is absent from S. bongori.
Divided into two segments: the smaller 14.5-kb portion containing a group of five ttr genes involved in tetrathionate reduction and seven ORFs of unknown function.
The larger 25.3-kb portion harbours genes important for virulence function. Four types of genes: ssa (for type III secretion system apparatus), ssr (for secretion system regulators), ssc (for secretion system chaperones, and sse (for secretion system effectors).
Coombes BK, et al., 2003. SseA is required for translocation of Salmonella pathogenicity island-2 effectors into host cells. Microbes Infect. 5(7):561-570.
Gallois A, et al., 2001. Salmonella pathogenicity island 2-encoded type III secretion system mediates exclusion of NADPH oxidase assembly from the phagosomal membrane. J. Immunol. 166(9):5741-5748.
Hensel M, 2000. Salmonella pathogenicity island 2. Mol. Microbiol. 36(5):1015-1023.
Hensel M, et al., 1998. Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages. Mol. Microbiol. 30(1):163-174.
Hensel M, et al., 1999. Molecular and functional analysis indicates a mosaic structure of Salmonella pathogenicity island 2. Mol. Microbiol. 31(2):489-498.
Kuhle V, Hensel M, 2002. SseF and SseG are translocated effectors of the type III secretion system of Salmonella pathogenicity island 2 that modulate aggregation of endosomal compartments. Cell. Microbiol. 4(12):813-824.
Lee AK, et al., 2000. OmpR regulates the two-component system SsrA-ssrB in Salmonella pathogenicity island 2. J. Bacteriol. 182(3):771-781.
Nikolaus T, et al., 2001. SseBCD proteins are secreted by the type III secretion system of Salmonella pathogenicity island 2 and function as a translocon. J. Bacteriol. 183(20):6036-6045.
Paesold G, et al., 2002. Genes in the Salmonella pathogenicity island 2 and the Salmonella virulence plasmid are essential for Salmonella-induced apoptosis in intestinal epithelial cells. Cell. Microbiol. 4(11):771-781.
Ruiz-Albert J, et al., 2003. SseA is a chaperone for the SseB and SseD translocon components of the Salmonella pathogenicity-island-2-encoded type III secretion system. Microbiology. 149:1103-1111.
Waterman SR, Holden DW, 2003. Functions and effectors of the Salmonella pathogenicity island 2 type III secretion system. Cell. Microbiol. 5(8):501-511.
Yu XJ, et al., 2002. SpiC is required for secretion of Salmonella Pathogenicity Island 2 type III secretion system proteins. Cell. Microbiol. 4(8):531-540.
Zurawski DV, Stein MA, 2003. SseA acts as the chaperone for the SseB component of the Salmonella Pathogenicity Island 2 translocon. Mol. Microbiol. 47(5):1341-1351.
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