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Pathogenicity islands in Helicobacter : cag-PAI


cag-PAI (Helicobacter)


View the legend cag1 cag2 cag3 virB1 virD4 virB11 cagZ virB10/cagY virB9/cagX virB6/cagW virB8/cagV cagU virB7/cagT cagS cagQ cagQ cagP cagM cagN virB5/cagL cagI cagH cagG cagF virB4/cagE cagD virB2/cagC cagA

Species: pylori
Strain: 26695
Replicon: chromosome
Accession: AE000511 (NC_000915)
Location: 547328~583481 bp
Size: 37 Kbp
G+C content (%): 35/39 (PAI/Genome)
Inserted locus:
Flanked by 31-bp direct repeats
Phenotype:
Contains 31 putative genes.
Five proteins encoded by the cag-PAI have substantial homology to component of type IV bacterial secretion system, including Ptl proteins of Bordetella pertusis, and Vir proteins of Agrobacterium tumefaciens.
Major function is the induction of the host cells to release pro-inflammatory chemokines.
Reference:
Censini S, et al., 1996. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc. Natl. Acad. Sci. USA. 93(25):14648-14653.
Fischer W, et al., 2001. Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8. Mol. Microbiol. 42(5):1337-1348.
Rohde M, et al., 2003. A novel sheathed surface organelle of the Helicobacter pylori cag type IV secretion system. Mol. Microbiol. 49(1):219-234.
Schmidt H, Hensel M, 2004. Pathogenicity islands in bacterial pathogenesis. Clin. Microbiol. Rev. 17(1):14-56.
Selbach M, et al., 2002. Functional analysis of the Helicobacter pylori cag pathogenicity island reveals both VirD4-CagA-dependent and VirD4-CagA-independent mechanisms. Infect. Immun. 70(2):665-671.
Tummuru MK, et al., 1995. Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells. Mol. Microbiol. 18(5):867-876.








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