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Pathogenicity islands in Francisella : FPI


View the legend pdpA1 pdpB1 iglE1 vgrG1 iglF1 iglG1 iglH1 iglH1 dotU1 iglI1 iglJ1 pdpC1 pdpE1 iglD1 iglC1 iglB1 iglB1 iglA1 pdpD1

Name: FPI
Full Name: Francisella Pathogenicity Island
Species: tularensis
Strain: SCHU S4
Location: chromosome
Start: 1379925
End: 1405040
Size(Kb): 25
Phenotype:
Encoding a uniq T6SS that is responsible for injecting effectors into the host cell to allow bacterial escape into the host cytosol
Remark:
25-kb genomic region that includes ~16-19 ORFs depending on the particular Francisella subspecies
8 ORFs share homology with proteins from type VI secretion systems
Presenting in all Francisella genomes
The strains highly virulent for humans exhibit the duplicated FPIs while the low virulence strains own only the single FPI copy
The first FPI identified gene was named iglC (intracellular growth locus C)
For the other group of the FPI ORFs the designation pathogenicity determinant protein (pdp) was adopted and the products of these ORFs were thus denoted PdpA, PdpB, PdpC and PdpD.
Reference:
Barker JR, et al., 2009. The Francisella tularensis pathogenicity island encodes a secretion system that is required for phagosome escape and virulence. Mol Microbiol 74(6):1459-70.
Broms JE, et al., 2010. The Role of the Francisella Tularensis Pathogenicity Island in Type VI Secretion, Intracellular Survival, and Modulation of Host Cell Signaling. Front Microbiol 1:136.
Nano FE, et al., 2004. A Francisella tularensis pathogenicity island required for intramacrophage growth. J Bacteriol 186(19):6430-6.
Nano FE, et al., 2007. The Francisella pathogenicity island. Ann N Y Acad Sci 1105:122-37.

 

 

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