|
Dispersin
(Anti-aggregation protein) |
 |
Encoded by a gene called aap lying immediately upstream of that encoding the AggR transcriptional activator, and that app is under AggR control. Dispersin's position on the bacterial surface (where it is accessible to immune cells) and its presence in the vast majority of EAEC strains make it a potential candidate for vaccine development. Exported by a putative ABC transporter complex encoded by a gene cluster designated aatPABCD. ... |
|
Enh loci
(Enhanced entry) |
|
RtxA gene from the enh1 locus seem to be involved in pore formation. ... |
|
DipA
(Deficient in intracellular replication A) |
|
A 353 amino acid protein with a Sec-dependent signal peptide, four Sel1-like repeats (SLR), and a C terminal coiled-coil (CC) domain. ... |
|
| OmpA |
|
A bacterial lipoprotein linking the OM to the cell wall so as to maintain the structural integrity and prevent altered surface exposure or release of PAMPs. ... |
|
RipA
(Required for intracellular proliferation, factor A) |
|
A small cytoplasmic membrane protein involved in bacterial intracellular replication and suppression of the proinflammatory immune response. ... |
|
PmiA
(Protozoa and macrophage infectivity loci protein) |
|
A transmembrane protein with three membrane-spanning regions. A novel virulence factor that is involved in intracellular survival and replication of L. pneumophila in macrophages and protozoan cells. ... |
|
Erp
(Exported repetitive protein) |
|
Surface-located protein. No homologue of Erp has been found in other bacterial species, making Erp a mycobacterial signature. ... |
|
| Isocitrate lyase |
|
PDB code: 1F61. Required for persistent infection. Isocitrate lyase is the initial enzyme in the glyoxylate shunt, a secondary metabolic pathway that allows bacteria to utilize fatty acids as carbon and energy sources when the availability of primary carbon sources is limiting. Isocitrate lyase, in combination with malate synthase, catalyzes the conversion of isocitrate to malate, a reaction that allows maintenance of the TCA cycle and synthesize carbohydrates from fatty acids. ... |
|
| MmaA4 |
|
Methyltransferase forms methoxy and keto derivatives of the meromycolic acid chain. ... |
|
| PcaA |
|
Mycolic acids are characteristic α-branched β-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia. In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the α-mycolate. ... |
|
| | | |
