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Chu (E. coli heme uptake) |
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chuA encodes for a 69-kDa outer membrane protein responsible for heme uptake. The chuA nucleotide sequence shows high homology to shuA gene of S. dysenteriae type 1. The gene is part of a larger locus, termed the heme transport locus, which appears to be widely distributed among pathogenic E. coli strains. ... |
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Shu |
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Heme utilization genes have been identified in numerous pathogens, including E. coli O157:H7, Yersinia pestis, Yersinia enterocolitica, Vibrio cholerae, Haemophilus influenzae, Neisseria meningitidis, etc. Two heme-uptake systems:. (1) direct binding of heme or heme-containing proteins to specific outer membrane receptors. (2) secretion of hemophores to interact with the hemoproteins and present it to specific receptors. ... |
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Hgp (Hemoglobin-binding protein) |
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H. influenzae has an absolute requirement for exogenously supplied heme for aerobic growth. Most of the pathway converting δ-aminolevulinic acid to heme is lost. So H. influenzae has derived several mechanism to use host heme-hemopexin, hemoglobin-haptoglobin as sources of heme iron for growth. Three hemoglobin- and hemoglobin-haptoglobin binding protein genes, hgpA, hgpB, and hgpC, contain lengths of tetrameric CCAA repeats. ... |
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HhuA (Hemoglobin:haptoglobin complexes binding protein) |
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Similar to HgpA, mediates binding of both hemoglobin:haptoglobin complexes and free hemoglobin. ... |
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HmbR |
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The gene encoding the hemoglobin receptor, hmbR, is located downstream of a gene involved in the catabolism of heme, hemO. Expression of HmbR undergoes phase variation due to slip-strand mispairing of poly(G) tracts within the hmbR gene. The advantage associated with phase-varying surface proteins is evasion of the host immune response. ... |
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HpuAB |
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Expression of HpuAB undergoes phase variation due to slip-strand mispairing of poly(G) tracts within the hpuA gene. ... |
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Heme receptor HutA |
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Heme receptors. ... |
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Heme receptor HutR |
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Heme receptors. ... |
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Hgp (Hemoglobin-binding protein) |
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H. influenzae has an absolute requirement for exogenously supplied heme for aerobic growth. Most of the pathway converting δ-aminolevulinic acid to heme is lost. So H. influenzae has derived several mechanism to use host heme-hemopexin, hemoglobin-haptoglobin as sources of heme iron for growth. Three hemoglobin- and hemoglobin-haptoglobin binding protein genes, hgpA, hgpB, and hgpC, contain lengths of tetrameric CCAA repeats. ... |
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Hgp (Hemoglobin-binding protein) |
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H. influenzae has an absolute requirement for exogenously supplied heme for aerobic growth. Most of the pathway converting δ-aminolevulinic acid to heme is lost. So H. influenzae has derived several mechanism to use host heme-hemopexin, hemoglobin-haptoglobin as sources of heme iron for growth. Three hemoglobin- and hemoglobin-haptoglobin binding protein genes, hgpA, hgpB, and hgpC, contain lengths of tetrameric CCAA repeats. ... |
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