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VF category: Protease (total 254 related VFs in database, current show from 1 to 10)
 
VF Bacteria Brief description
CpaA
(Coagulation targeting metallo-endopeptidase of A. baumannii)
Acinetobacter
(A. baumannii BJAB0715)
 CpaA is the best characterized and most abundant effector secreted by several medically relevant Acinetobacter strains. CpaA stability and secretion depend on the membrane-bound chaperone CpaB, which is encoded adjacent to CpaA. ...
InhA
(Immune inhibitor A)
Bacillus
(B. anthracis str. Sterne)
 A secreted and cell associated protease plays a role in anthrax virulence through cleavage of numerous host substrates including host proteins involved in the coagulation cascade so as to potentially facilitate circulatory dissemination of bacteria. A regulatory factor of adhesin BslA expression. ...
CPAF
(Chlamydial protease-like activating factor )
Chlamydia
(C. trachomatis D/UW-3/CX)
 Highly conserved between members of the Chlamydiaceae. Secreted chlamydial serine protease mediating the evasion of the innate immune response. Inhibits the complement activation pathway by degrading complement factor C3 and B. Degrading the antimicrobial peptides with anti-chlamydial activity. ...
Cwp84
(Cell wall protein 84)
Clostridium
(C. difficile 630)
 Increase adhesion and colonization. A surface exposed and conserved cysteine protease responsible for SlpA cleavage and the maturation of the S-layer in C. difficile. Involved in host tissue degradation and bacterial colonization by cleaving extracellular matrix components fibronectin, laminin, and vitronectin. ...
Gelatinase
Enterococcus
(E. faecalis V583)
 A member of the matrix metalloproteinase (MMP) family. Gelatinase expression is controlled via the global virulence-regulating locus, Fsr. ...
SprE
Enterococcus
(E. faecalis V583)
 Encoding a 26-kDa protein that shares homology with the S. aureus V8 protease. The expression of both gelE and sprE is dependent on the fsr genes. ...
StcE
(Secreted protease of C1 esterase inhibitor from EHEC)
Escherichia
(E. coli O157:H7 str. EDL933)
 Encoded within the pO157 plasmid that belongs to the family of serine protease inhibitor. Secreted by a type II secretory apparatus also encoded within pO157 plasmid and is transcriptionally activated by the Ler, so the production of StcE is coupled with activation of the LEE genes. ...
IgA1 protease
Haemophilus
(H. influenzae Rd KW20)
 Two classes of IgA1 proteases: cleavage at either a prolyl-seryl (type1) or four amino acids away at a prolyl-threoryl bond (type 2). Display polymorphisms and antigenic variation. ...
Mpl
Listeria
(L. monocytogenes EGD-e)
 Zinc-metalloprotease to process PlcB. ...
Alkaline protease
Pseudomonas
(P. aeruginosa PAO1)
 Secreted by type I secretion pathway. Consists of two domains: an N-terminal catalytic domain of about 230 residues and a C-terminal domain of similar size that is required for secretion of the enzyme across the periplasm into the external medium. PDB code: 1KAP. ...
   


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