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VF category: Metal uptake (total 935 related VFs in database, current show from 1 to 10)
 
VF Bacteria Brief description
HemO cluster
Acinetobacter
(A. baumannii ACICU)
 Current studies show the hemO gene cluster is required for optimal utilization of heme in A. baumannii hypervirulent strains. The hemO gene cluster encodes a secreted hemophore. ...
Bacillibactin
Bacillus
(B. cereus ATCC 10987)
 Catechol-based siderophore. Disruption of the siderophore bacillibactin production drastically reduces the ability of B. cereus to utilize ferritin for growth and results in attenuated bacterial virulence in insects. ...
Aerobactin
Escherichia
(E. coli CFT073)
 A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae. TonB-dependent iron transport. ...
Chu
(E. coli heme uptake)
Escherichia
(E. coli O157:H7 str. EDL933)
 chuA encodes for a 69-kDa outer membrane protein responsible for heme uptake. The chuA nucleotide sequence shows high homology to shuA gene of S. dysenteriae type 1. The gene is part of a larger locus, termed the heme transport locus, which appears to be widely distributed among pathogenic E. coli strains. ...
Chu
(E. coli heme uptake)
Escherichia
(E. coli CFT073)
 chuA encodes for a 69-kDa outer membrane protein responsible for heme uptake. The chuA nucleotide sequence shows high homology to shuA gene of S. dysenteriae type 1. The gene is part of a larger locus, termed the heme transport locus, which appears to be widely distributed among pathogenic E. coli strains. ...
Enterobactin
Escherichia
(E. coli CFT073)
 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three. ...
Salmochelin siderophore
Escherichia
(E. coli CFT073)
 Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi. ...
Aerobactin
Klebsiella
(K. pneumoniae subsp. pneumoniae NTUH-K2044)
 Aer is typically plasmid-encoded. The siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae. ...
Ent
(Enterobactin)
Klebsiella
(K. pneumoniae subsp. pneumoniae NTUH-K2044)
 Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. ...
Sal
(Salmochelin)
Klebsiella
(K. pneumoniae subsp. pneumoniae NTUH-K2044)
 Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport. A major trigger of inflammation and bacterial dissemination induced during K. pneuminiae lung infection. ...
   


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