VF category: T3SS components (total 121 related VFs in database, current show from 1 to 10)
VF Bacteria Brief description
(A. salmonicida subsp. salmonicida A449)
Similar to the Yersinia T3SS. A needle-like structure, often described as an "injectisome" that can inject effectors directly into the cytoplasm of target cells. Five effectors have been described: AexT, AexU, AopP, AopH and AopO. AexT and AexU are bifunctional toxins that contain a GTPase activating domain, allowing the interruption of host cell-signalling pathways and an ADP-ribosylating domain that can disrupt the host cytoskeleton, leading to the induction of apoptosis. AopP (NF-κB inhibitor), AopH (tyrosine phosphatase) and AopO (serine/threonine kinase), all are able to interrupt host cell signalling pathways and induce toxicity. ...
(Type III secretion system)
(B. pertussis Tohama I)
B. pertussis has genes that could encode a TTSS, but they seem not to be expressed. B. bronchiseptica and ovine B. parapertussis strains, by contrast, do have a functional TTSS. ...
Bsa T3SS
(B. pseudomallei K96243)
Mxi-SpaA like T3SS, shares homology to Salmonella SPI-1 and Shigella T3SSs. Two additional T3SSs are discovered in B. Pseudomallei. T3SS1 is only present in B. pseudomallei and not in Burkholderia mallei or Burkholderia thailandensis, whereas T3SS2 and T3SS3 (Bsa) are present in all three species. T3SS1 and T3SS2 are closely related to the T3SS of the plant pathogens R. solanacearum and Xanthomonas spp. T3SS1 and T3SS2 are required during B. pseudomallei infection of tomato plants but not for infection of hamsters. ...
(Type III secretion system)
(C. trachomatis D/UW-3/CX)
Type III secretion genes of Proteobacteria are usually tightly clustered in a pathogenicity island or on a plasmid, suggesting that they can be horizontally transferred as a unit. But chlamydial type III secretion loci are dispersed in at least three different chromosomal locations. The G+C contents of these loci, are similar to the overall G+C content of the genome, suggesting that the type III system has been present in chlamydiae for a long time and has been essential to their parasitic lifestyle. On the basis of this loose retainment of operon organization and the significant divergence from other type III systems, it has been postulated an ancient acquisition of the type III system by chlamydiae. ...
(Type III secretion system)
(E. coli O157:H7 str. EDL933)
Encoded on the pathogenicity island known as the locus of enterocyte effacement (LEE). Injects Tir and other effector molecules directly into the host cell. Effector molecules activate cell-signaling pathways, causing alterations in the host cell cytoskeleton and resulting in the depolymerization of actin and the loss of microvilli. ...
(Type III secretion system)
(E. coli O127:H6 str. E2348/69)
Encoded on a 35-kb chromosomal pathogenicity island known as the locus of enterocyte effacement (LEE). ...
TTSS (SPI-1 encode)
(S. enterica subsp. enterica serovar Typhimurium str. LT2)
TTSS injectisome is composed of a multi-ring base anchored to the outer membrane through the outer rings 1 and 2 and to the inner membrane through the inner rings 1 and 2. An inner rod, composed of the protein PrgJ, traverses the base and joins the needle substructure, composed of a single protein, PrgI, at the apical side. The base is composed of three proteins, namely InvG, PrgH and PrgK. ...
TTSS (SPI-2 encode)
(S. enterica subsp. enterica serovar Typhimurium str. LT2)
Secretes effector proteins to facilitate the replication of intracellular bacteria within membrane-bound Salmonella-containing vacuoles (SCVs). ...
(Type III secretion system)
(S. flexneri 2a str. 301)
Encoded on the large virulence plasimid. The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface. Abbreviations:Ipg for invasion plasmid gene. Spa for surface presentation of invasion plasmid antigens. Mxi for membrane excretion of Ipa. ...
(V. parahaemolyticus RIMD 2210633)
Chromosome I encoded. Similar to the Ysc secretion system in Yersinia. T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698. ...

Page  1  2  3  4  5  6  7  8  9  10  11  ...  13
Back to top
2004-2023 IPB, CAMS&PUMC