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| K1 capsule |
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The K1 capsular polysaccharide are predominant (approximately 80%) among isolates from neonatal E. coli meningitis. The K1 capsule, an α-2,8-linked polymer of sialic acid (polySia), are encoded by the kps gene cluster which is divided into three functional regions. The central region 2 (neuE, -C, -A, -B, -D) is unique for a given polysaccharide antigen and encoding genes responsible for the synthesis of the K-specific serotype. In contrast, genes in regions 1 and 3 are conserved among E. coli synthesizing serologically distinct capsules. Region 1 contains six genes (kpsF, -E, -D, -U, -C and -S). Region 3 contains two genes (kpsM and kpsT). The gene products from these regions are needed for transport of the capsular polysaccharide across the cytoplasmic membrane (KpsM and KpsT) and assembly onto the cell's surface (KpsD and KpsE). ... |
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AipA
(A. phagocytophilum invasion protein A) |
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Binding domain lies within residues 9 to 21. Promote optimal bacterial entry into mammalian host cells. ... |
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Asp14
(14-kDa A. phagocytophilum surface protein) |
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Binding domain lies within residues 113 to 124. Promote optimal bacterial entry into mammalian host cells. ... |
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| OmpA |
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High degree of sequence conservation. Binding domain lies within amino acids 59 to 74. Binds to α2,3-sialic acid of sialyl Lewis x, this receptor-ligand interaction is required for efficient cellular entry. ... |
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CiaB
(Campylobacter invasion antigen B) |
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73-kDa protein secreted by the flagellin export apparatus. CiaB lacks an identifiable signal sequence, and an environmental stimulus is required to induce Cia protein secretion, but there is no evidence of a type III secretion system. ... |
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CiaC
(Campylobacter invasion antigen C) |
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Exported via the flagellar T3SS. Required for maximal invasion of host cells. ... |
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Ctad1
(C. trachomatis adhesin 1) |
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Ctad1 homolog is found in all members of the genus Chlamydia. Ctad1 is extremely well conserved among C. trachomatis serovars with identities between 98% and 100%, while the identities and homologies with homologs from other chlamydia species vary from 51% to 83%, and 69% to 90% respectively. Ctad1 homologs with significant identities and homologies can also be identified in the chlamydia-like organisms Parachlamydia, Waddlia and Simkania. ... |
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MOMP
(Major outer membrane protein) |
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Approximately 40 kDa in size, with five genetically conserved domains and four variable domains that are used to determine the serovar within each species. Characterzed by an N-terminal domain that forms an eight-stranded, anti-parallel β barrel embedded in the outer membrane. The eight strands are connected by four long loops at the outer membrane surface and three short periplasmic turns of the molecule. ... |
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| AslA |
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Homology to aslA of E. coli K12. Based on its protein sequence, AslA is predicted to be a member of the arylsulfatase family of enzymes that contains highly conserved sulfatase motifs, but E. coli AslA failed to exhibit in vitro arylsulfatase activity. ... |
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Ibes
(Invasion of brain endothelial cells) |
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ibeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. ... |
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