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| Type I pili |
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Short-rigid pili. Chaperone-usher pathway assembled pili. Involved in the initial stages of colonisation. ... |
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| Fimbriae |
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The major subunits form the two predominant Bordetella fimbrial serotypes: Fim2 and Fim3. fimX is expressed only at very low levels. fimN, the fourth fimbrial locus is identified in B. bronchiseptica. The fim genes are subject to fimbrial phase variation by a mechanism involved in slipped-stand mispairing within a stretch of cytosine residues located between the -10 and -35 elements of the fim2, fim3, fimX and fimN promoters. FimD is the minor fimbrial subunit for all fimbrial serotypes. It forms the tip adhesin. ... |
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| Dr adhesins |
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The Dr family of adhesins of E. coli is associated with urinary tract infections (UTI), in particular cystitis and pregnancy-associated pyelonephritis, and diarrhoeal disease. The Dr family includes fimbrial adhesins, such as the Dr haemagglutinin (O75X adhesin) and F1845, and afimbrial adhesins, such as AFA-I, AFA-II, AFA-III, AFA-IV, Nfa-I and Dr-II. ... |
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| F1C fimbriae |
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A nonhemagglutinating adherence factor and is expressed by approximately 14% of the E. coli known to cause urinary tract infections and 7% of E. coli fecal isolates. Genetically homologous to S fimbriae, but differ in their receptor specificity. ... |
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| P fimbriae |
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Mannose-resistant (MRHA). Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims. The pap operon is a useful example of pilus assembly since it contains many conserved features:. PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane. PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM. The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH. At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF. ... |
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| S fimbriae |
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Consists of the major subunit SfaA and minor subunits SfaG, SfaS, and SfaH. SfaS is preferentially located at the tip of S fimbriae. ... |
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| S fimbriae |
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Encoded by sfa operon composed of nine genes. Composed of a major subunit SfaA and three minor subunits SfaG, SfaH and SfaS. The SfaS subunit has been localized to S pilus tips and can mediate bacterial interactions with sialic acid residues on receptors. ... |
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| Type 1 fimbriae |
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Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose. The genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI. Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The σ70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases. ... |
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| Type I fimbriae |
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Type I fimbriae are expressed in 90% of both clinical and environmental K. pneumoniae isolates as well as almost all members of the Enterobacteriaceae. Type I fimbriae are filamentous, membrane-bound, adhesive structures composed primarily of FimA subunits, with the FimH subunit on the tip. ... |
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Lpf
(Long polar fimbriae) |
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Chaperone-usher assembly pathway. Mediate attachment to the Peyer's patches. ... |
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